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. 2006 Aug 7;95(3):355-62.
doi: 10.1038/sj.bjc.6603252. Epub 2006 Jul 11.

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

M-N Didelot-Rousseau  1 , N Nagot, V Costes-Martineau, X Vallès, A Ouedraogo, I Konate, H A Weiss, P Van de Perre, P Mayaud, M Segondy; Yerelon Study Group
Affiliations

Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

M-N Didelot-Rousseau et al. Br J Cancer. .

Abstract

Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2-7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio (PR) = 1.61, 95% confidence interval (CI): 1.4-1.8). High-risk HPV types (71 vs 40%, PR = 1.79, 95% CI: 1.5-2.2), in particular HPV-16+18 (22 vs 9%, PR = 2.35, 95% CI: 1.4-4.0), and multiple HPV infections (56 vs 23%, PR = 2.45, 95% CI: 1.8-3.3) were more prevalent in HIV-1-infected women. High-grade SIL (HSIL) was identified in 3.8% of the women. Human immunodeficiency virus type 1 infection was strongly associated with presence of HSIL (adjusted odds ratio = 17.0; 95% CI 2.2-134.1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine.

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Figures

Figure 1
Figure 1
Distribution of HPV types identified among 349 high-risk women in Bobo-Dioulasso, Burkina Faso.
Figure 2
Figure 2
Distribution of HPV infection according to age and HIV-1 status among 349 women in Bobo Dioulasso, Burkina Faso. Numbers of women in groups are indicated at the top of bars. The hatched part of the bar represents the proportion of women infected with at least one high-risk HPV type, whereas the unicoloured part represents the proportion of women infected with low-risk HPV types only.
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