Clinical Trial
doi: 10.1111/j.1365-2133.1991.tb14173.x.
The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen
Affiliations
- PMID: 1683252
- DOI: 10.1111/j.1365-2133.1991.tb14173.x
Item in Clipboard
Clinical Trial
The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen
Br J Dermatol.
1991 Oct.
Abstract
An open cross-over study was performed to assess the effects of astemizole, cetirizine and loratadine on weal and flare reactions to intradermal histamine, codeine and house dust mite antigen. Percentage inhibition of weal area, flare area and weal volume was greatest for cetirizine, then astemizole and smallest for loratadine. Wealing due to mast-cell degranulation with either codeine or antigen was less inhibited by all three antihistamines than that due to histamine itself. Time-course studies revealed similarities between wealing provoked by codeine and histamine but different characteristics to that induced by antigen.
Similar articles
-
Effects of cetirizine, loratadine and terfenadine on histamine weal and flare reactions.Skin Pharmacol. 1992;5(1):29-33. doi: 10.1159/000211014. Skin Pharmacol. 1992. PMID: 1533530 Clinical Trial.
-
Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine.Ann Allergy. 1990 Aug;65(2):139-42. Ann Allergy. 1990. PMID: 1974399 Clinical Trial.
-
The effect of cetirizine and loratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis.Inflamm Res. 1996 Sep;45(9):486-90. doi: 10.1007/BF02252321. Inflamm Res. 1996. PMID: 8891761 Clinical Trial.
-
Recent advances in H1-receptor antagonist treatment.J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):995-9. doi: 10.1016/s0091-6749(05)80242-8. J Allergy Clin Immunol. 1990. PMID: 1979802 Review.
-
The second-generation antihistamines. What makes them different?Postgrad Med. 1991 May 1;89(6):87-8, 91-4, 99. doi: 10.1080/00325481.1991.11700919. Postgrad Med. 1991. PMID: 1673571 Review.
Cited by
-
Astemizole. A nonsedating antihistamine with fast and sustained activity.Clin Rev Allergy. 1993 Spring;11(1):35-63. doi: 10.1007/BF02802293. Clin Rev Allergy. 1993. PMID: 8319160 Review. No abstract available.
-
Urticaria. Recognition, causes and treatment.Drugs. 1994 Nov;48(5):717-30. doi: 10.2165/00003495-199448050-00006. Drugs. 1994. PMID: 7530629 Review.
-
Cetirizine: a review of its use in allergic disorders.Drugs. 2004;64(5):523-61. doi: 10.2165/00003495-200464050-00008. Drugs. 2004. PMID: 14977391
-
Predicting and establishing the clinical efficacy of a histamine h(1)-receptor antagonist : desloratadine, the model paradigm.Clin Drug Investig. 2005;25(3):153-64. doi: 10.2165/00044011-200525030-00001. Clin Drug Investig. 2005. PMID: 17523764
-
MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway.J Invest Dermatol. 2021 May;141(5):1286-1296.e4. doi: 10.1016/j.jid.2020.09.017. Epub 2020 Oct 13. J Invest Dermatol. 2021. PMID: 33058860 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
