Analysis of inflammation
- PMID: 16834553
- DOI: 10.1146/annurev.bioeng.8.061505.095708
Analysis of inflammation
Abstract
In the past, inflammation has been associated with infections and with the immune system. But more recent evidence suggests that a much broader range of diseases have telltale markers for inflammation. Inflammation is the basic mechanism available for repair of tissue after an injury and consists of a cascade of cellular and microvascular reactions that serve to remove damaged and generate new tissue. The cascade includes elevated permeability in microvessels, attachment of circulating cells to the vessels in the vicinity of the injury site, migration of several cell types, cell apoptosis, and growth of new tissue and blood vessels. This review provides a summary of the major microvascular, cellular, and molecular mechanisms that regulate elements of the inflammatory cascade. The analysis is largely focused on the identification of the major participants, notably signaling and adhesion molecules, and their mode of action in the inflammatory cascade. We present a new hypothesis for the generation of inflammatory mediators in plasma that are derived from the digestive pancreatic enzymes responsible for digestion. The inflammatory cascade offers a large number of opportunities for development of quantitative models that describe various aspects of human diseases.
Similar articles
-
Innate immunity of the liver microcirculation.Cell Tissue Res. 2011 Jan;343(1):85-96. doi: 10.1007/s00441-010-1058-5. Epub 2010 Oct 30. Cell Tissue Res. 2011. PMID: 21049273 Review.
-
Inflammatory mechanisms in atherosclerosis.Hamostaseologie. 2014;34(1):63-71. doi: 10.5482/HAMO-13-09-0050. Epub 2013 Dec 17. Hamostaseologie. 2014. PMID: 24343521 Review.
-
[The immune system and inflammatory diseases].Ugeskr Laeger. 2008 Jun 9;170(24):2110-5. Ugeskr Laeger. 2008. PMID: 18565290 Review. Danish.
-
Research in practice: Regulatory T cells - targets for therapeutic approaches?J Dtsch Dermatol Ges. 2011 Jan;9(1):8-11. doi: 10.1111/j.1610-0387.2010.07503.x. Epub 2010 Sep 7. J Dtsch Dermatol Ges. 2011. PMID: 21166772 Review. English, German.
-
Apolipoprotein M likely extends its anti-atherogenesis via anti-inflammation.Med Hypotheses. 2007;69(1):136-40. doi: 10.1016/j.mehy.2006.10.052. Epub 2007 Jan 10. Med Hypotheses. 2007. PMID: 17218068
Cited by
-
Tissue-engineered model for real-time monitoring of liver inflammation.Tissue Eng Part C Methods. 2011 Jan;17(1):113-22. doi: 10.1089/ten.TEC.2009.0782. Epub 2010 Sep 28. Tissue Eng Part C Methods. 2011. PMID: 20684748 Free PMC article.
-
MAIDS resistance-associated gene expression patterns in secondary lymphoid organs.Immunogenetics. 2008 Sep;60(9):485-94. doi: 10.1007/s00251-008-0312-4. Epub 2008 Jul 9. Immunogenetics. 2008. PMID: 18612634
-
A Bird's Eye Review of Recent Reports on 1,3,4-oxadiazoles' Anti-inflammatory Insights Perspectives.Curr Org Synth. 2024;21(5):595-606. doi: 10.2174/1570179420666230508124847. Curr Org Synth. 2024. PMID: 37157211 Review.
-
Phytochemical Profiling, Anti-Inflammatory, Anti-Oxidant and In-Silico Approach of Cornus macrophylla Bioss (Bark).Molecules. 2022 Jun 24;27(13):4081. doi: 10.3390/molecules27134081. Molecules. 2022. PMID: 35807324 Free PMC article.
-
Immunonutrition: facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance.Front Immunol. 2023 Sep 29;14:1241615. doi: 10.3389/fimmu.2023.1241615. eCollection 2023. Front Immunol. 2023. PMID: 37841275 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous