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Review
. 2006;10(4):218.
doi: 10.1186/cc4958.

Pro/con debate: octreotide has an important role in the treatment of gastrointestinal bleeding of unknown origin?

Yaseen Arabi  1 , Bandar Al Knawy, Alan N Barkun, Marc Bardou
Affiliations
Review

Pro/con debate: octreotide has an important role in the treatment of gastrointestinal bleeding of unknown origin?

Yaseen Arabi et al. Crit Care. 2006.

Abstract

Whether it is the primary reason for admission or a complication of critical illness, upper gastrointestinal bleeding is commonly encountered in the intensive care unit. In this setting, in the absence of endoscopy, intensivists generally provide supportive care (transfusion of blood products) and acid suppression (such as proton pump inhibitors). More recently, octreotide (a somatostatin analogue) has been used in such patients. However, its precise role in patients with upper gastrointestinal bleeding is not necessarily clear and the drug is associated with significant costs. In this issue of Critical Care, two expert teams debate the merits of using octreotide in non-variceal upper gastrointestinal bleeding.

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References

    1. Reubi JC, Schaer JC, Laissue JA, Waser B. Somatostatin receptors and their subtypes in human tumors and in peritumoral vessels. Metabolism. 1996;45(Suppl 1):39–41. doi: 10.1016/S0026-0495(96)90077-3. - DOI - PubMed
    1. Nevens F. Review article: a critical comparison of drug therapies in currently used therapeutic strategies for variceal haemorrhage. Aliment Pharmacol Ther. 2004;20(Suppl 3):18–22. doi: 10.1111/j.1365-2036.2004.02110.x. discussion 23. - DOI - PubMed
    1. Ludwig D, Schadel S, Bruning A, Schiefer B, Stange EF. 48-hour hemodynamic effects of octreotide on postprandial splanchnic hyperemia in patients with liver cirrhosis and portal hypertension: double-blind, placebo-controlled study. Dig Dis Sci. 2000;45:1019–1027. doi: 10.1023/A:1005553914878. - DOI - PubMed
    1. Clarke DL, McKune A, Thomson SR. Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs. Surg Endosc. 2003;17:1570–1572. doi: 10.1007/s00464-002-9274-z. - DOI - PubMed
    1. Sgouros SN, Bergele C, Viazis N, Avgerinos A. Somatostatin and its analogues in peptic ulcer bleeding: facts and pathophysiological aspects. Dig Liver Dis. 2006;38:143–148. doi: 10.1016/j.dld.2005.11.012. - DOI - PubMed

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