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. 2006 May 20;20(6):567-72.
doi: 10.1080/14786410500183944.

New alkaloids from Phoebe grandis (Nees) Merr

Khalijah Awang  1 , Mat Ropi Mukhtar, A Hamid A Hadi, Marc Litaudon, Jalifah Latip, Noor Rain Abdullah
Affiliations

New alkaloids from Phoebe grandis (Nees) Merr

Khalijah Awang et al. Nat Prod Res. .

Abstract

The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 microg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.

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