Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Oct;21(10):1135-41.
doi: 10.14670/HH-21.1135.

Gamma-aminobutyric acid (GABA) and cell proliferation: focus on cancer cells

M Watanabe  1 , K Maemura, K Oki, N Shiraishi, Y Shibayama, K Katsu
Affiliations
Review

Gamma-aminobutyric acid (GABA) and cell proliferation: focus on cancer cells

M Watanabe et al. Histol Histopathol. 2006 Oct.

Abstract

In addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABA(A) receptors and/or metabotropic GABA(B) receptors. In this review, the current state of knowledge regarding the role of the GABAergic system in peripheral nonneuronal cell proliferation is described, and recent advances in elucidation of the mechanisms leading to cell proliferation are discussed.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources