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. 2006 Jul 12:7:341.
doi: 10.1186/1471-2105-7-341.

Curation of complex, context-dependent immunological data

Randi Vita  1 , Kerrie Vaughan, Laura Zarebski, Nima Salimi, Ward Fleri, Howard Grey, Muthu Sathiamurthy, John Mokili, Huynh-Hoa Bui, Philip E Bourne, Julia Ponomarenko, Romulo de Castro Jr, Russell K Chan, John Sidney, Stephen S Wilson, Scott Stewart, Scott Way, Bjoern Peters, Alessandro Sette
Affiliations

Curation of complex, context-dependent immunological data

Randi Vita et al. BMC Bioinformatics. .

Abstract

Background: The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http://www.immuneepitope.org.

Description: To identify and extract relevant data from the scientific literature in an efficient and accurate manner, novel processes were developed for manual and semi-automated annotation.

Conclusion: Formalized curation strategies enable the processing of a large volume of context-dependent data, which are now available to the scientific community in an accessible and transparent format. The experiences described herein are applicable to other databases housing complex biological data and requiring a high level of curation expertise.

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Figures

Figure 1
Figure 1
Epitope related references present in PubMed. a. References related to epitopes derived from all sources. b. References related to epitopes derived from NIAID Category A–C pathogens.
Figure 2
Figure 2
The IEDB curation process and statistics.
Figure 3
Figure 3
Relationships between an epitope and contexts.
Figure 4
Figure 4
Total references processed as of February 5th 2006.
See this image and copyright information in PMC

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