Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jul;12(7):1119-21.
doi: 10.3201/eid1207.051531.

Smallpox during pregnancy and maternal outcomes

Affiliations

Smallpox during pregnancy and maternal outcomes

Hiroshi Nishiura. Emerg Infect Dis. 2006 Jul.

Abstract

A historical study evaluated maternal outcomes in pregnancy complicated by smallpox. The overall case fatality was estimated to be 34.3% (95% confidence interval [CI] 31.4-37.1), and the proportion of miscarriage or premature birth was estimated to be 39.9% (95% CI 36.5-43.2). Vaccination before pregnancy reduced the risk for death.

PubMed Disclaimer

Figures

Figure
Figure
Maternal outcomes in pregnancies complicated by smallpox from data from 19th- and early 20th-century outbreaks. A) Case fatalities and B) proportions of miscarriage or premature birth are shown. Miscarriage and premature birth before maternal death are included. For additional study information, see references.
Figure A1
Figure A1
Flow diagram of the study selection process.

References

    1. Henderson DA, Inglesby TV, Bartlett JG, Ascher MS, Eitzen E, Jahrling PB, et al. Smallpox as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA. 1999;281:2127–37. 10.1001/jama.281.22.2127 - DOI - PubMed
    1. Suarez VR, Hankins GD. Smallpox and pregnancy: from eradicated disease to bioterrorist threat. Obstet Gynecol. 2002;100:87–93. 10.1016/S0029-7844(02)02048-3 - DOI - PubMed
    1. Fenner F, Henderson DA, Arita I, Ježek Z, Ladnyi ID. Smallpox and its eradication. Geneva: World Health Organization; 1988. [cited 2006 May 4]. Available from http://whqlibdoc.who.int/smallpox/9241561106.pdf
    1. Rao AR, Prahlad I, Swaminathan M, Lakshmi A. Pregnancy and smallpox. J Indian Med Assoc. 1963;40:353–63. - PubMed
    1. Rao AR. Haemorrhagic smallpox: a study of 240 cases. J Indian Med Assoc. 1964;43:224–9. - PubMed

Publication types

LinkOut - more resources