Comparative Study
doi: 10.1016/j.mimet.2006.05.018.
Epub 2006 Jul 11.
A biased detection of the flexible genome content: missing large restriction fragments in comparative genomics
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- PMID: 16837088
- DOI: 10.1016/j.mimet.2006.05.018
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Comparative Study
A biased detection of the flexible genome content: missing large restriction fragments in comparative genomics
J Microbiol Methods.
2006 Dec.
Abstract
Gene content variation between closely related bacteria is largely due to mobile elements and gene erosion. Various techniques are available to assess this variation, yet biased pools of restriction fragments have been used in several comparative genomics studies. Excluding important large restriction fragments from the actual hybridisation or from post-hybridisation amplification reactions compromise the comprehensiveness of these studies.
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