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. 2007 Feb;80(4):342-5.
doi: 10.1007/s00420-006-0125-4. Epub 2006 Jul 13.

Inverse relationship between serum erythropoietin and blood lead concentrations in Kathmandu tricycle taxi drivers

Susumu Sakata  1 , Satoshi Shimizu, Kumiko Ogoshi, Kazuko Hirai, Yoshimi Ohno, Takashi Kishi, Jeevan B Sherchand, Masako Utsumi, Munetaka Shibata, Miyako Takaki, Masatsugu Ueda, Ippei Mori
Affiliations

Inverse relationship between serum erythropoietin and blood lead concentrations in Kathmandu tricycle taxi drivers

Susumu Sakata et al. Int Arch Occup Environ Health. 2007 Feb.

Abstract

Objective: Kathmandu tricycle taxi drivers, whose environmental lead (Pb) exposure is ascribable mainly to vehicular exhaust, were studied to examine a dose-response relationship between blood Pb (Pb-B) and serum erythropoietin (sEPO) concentrations.

Methods: Subjects were 27 drivers and 9 non-drivers. They were non-anemic healthy men with normal renal function. Pb-B was measured by an atomic absorption spectrometer with a graphite furnace, and sEPO was determined with a sandwich-type enzyme-linked immunosorbent assay.

Results: sEPO levels in drivers were lower than those of non-drivers, while Pb-B levels in drivers were higher than those of non-drivers. There was an inverse relationship between Pb-B and sEPO.

Conclusions: The data suggest that Pb inhibits renal EPO production in a dose-dependent manner in persons with subclinical Pb toxicity. sEPO may serve as an early biochemical marker of subclinical Pb toxicity.

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