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Case Reports
. 2006 Sep;81(9):713-6.
doi: 10.1002/ajh.20688.

Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi  1 , Yoshio Katayama, Shiro Kubonishi, Toshiyuki Watanabe, Yukari Watanabe, Ken-ichi Matsuoka, Yoshinobu Maeda, Noriko Namba, Taro Masunari, Ryusuke Nasu, Kazuma Ikeda, Mitsune Tanimoto
Affiliations
Free article
Case Reports

Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi et al. Am J Hematol. 2006 Sep.
Free article

Abstract

We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

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