Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Jul;18(7):703-7.
doi: 10.1021/jm00241a013.

Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone

F Arcamone, S Penco, A Vigevani, S Redaelli, G Franchi, A DiMarco, A M Casazza, T Dasdia, F Formelli, A Necco, C Soranzo

Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone

F Arcamone et al. J Med Chem. 1975 Jul.

Abstract

The synthesis of 4'-epi-daunorubicin and of 4'-epi-adriamycin was performed by condensation of 2,3,6-trideoxy-3-trifluoroacetamido-4-O-trifluoroacetyl-alpha-L-arabino-hexopyranosyl chloride with daunomycinone or the protected adriamycinone derivative 17, respectively. Both the alpha and beta anomers were obtained and characterized. All new compounds are biologically active in cultured cells and the alpha anomers display noticeable activity in experimental tumors in mice. Interestingly, 4'-epi-adriamycin (4) appears nontoxic to cultured heart cells up to a concentration of 5 mug/ml.

PubMed Disclaimer

MeSH terms

LinkOut - more resources