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. 2006 Jul 21;71(15):5489-97.
doi: 10.1021/jo060397a.

Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: scope and limitations

Nuno R Candeias  1 , Pedro M P Gois, Carlos A M Afonso
Affiliations

Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: scope and limitations

Nuno R Candeias et al. J Org Chem. .

Abstract

Preferential Rh(II) carbenoid intramolecular C-H versus O-H insertion derived from alpha-diazo-acetamides can be achieved in water by using an appropriate combination of the catalyst and amide groups, which creates a larger hydrophobic environment around the reactive carbenoid center.

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