Review
doi: 10.1016/0140-6736(91)92382-c.
Chirality in antirheumatic drugs
Affiliations
- PMID: 1683980
- DOI: 10.1016/0140-6736(91)92382-c
Item in Clipboard
Review
Chirality in antirheumatic drugs
Lancet.
1991 Dec.
Abstract
Use of chiral molecules in clinical practice may cause problems because different chiral forms of a drug (enantiomers) may have different biological activities--yet clinicians have little awareness of these risks. After discussion of the chemical conventions used to describe chirality, examples of the influence of chirality on the efficacy and toxicity of antirheumatic drugs are given. It is recommended that single enantiomers should be used in biological experiments and clinical trials.
Comment in
-
Chirality of penicillamine.Lancet. 1992 Jan 25;339(8787):254. doi: 10.1016/0140-6736(92)90069-f. Lancet. 1992. PMID: 1346220 No abstract available.
-
Thalidomide enantiomers.Lancet. 1992 Feb 8;339(8789):365. doi: 10.1016/0140-6736(92)91684-z. Lancet. 1992. PMID: 1346437 No abstract available.
-
Chirality and drug development.Lancet. 1992 Feb 22;339(8791):495. doi: 10.1016/0140-6736(92)91104-g. Lancet. 1992. PMID: 1346848 No abstract available.
-
S(+) versus racemic ibuprofen.Lancet. 1992 Mar 14;339(8794):681. doi: 10.1016/0140-6736(92)90842-q. Lancet. 1992. PMID: 1347370 Clinical Trial. No abstract available.
Similar articles
-
Chirality and nonsteroidal anti-inflammatory drugs.Drugs. 1996;52 Suppl 5:47-58. doi: 10.2165/00003495-199600525-00006. Drugs. 1996. PMID: 8922556 Review.
-
Chiral NSAIDS: so what?Agents Actions Suppl. 1993;44:15-22. Agents Actions Suppl. 1993. PMID: 8372724 Review.
-
Single Nanochannel Platform for Detecting Chiral Drugs.Anal Chem. 2017 Jan 17;89(2):1110-1116. doi: 10.1021/acs.analchem.6b02682. Epub 2016 Dec 22. Anal Chem. 2017. PMID: 28194990
-
Chiral self assembled monolayers as resolving auxiliaries in the crystallization of valine.J Pharm Sci. 2010 Sep;99(9):3931-40. doi: 10.1002/jps.22237. J Pharm Sci. 2010. PMID: 20533552
-
Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.Clin Pharmacokinet. 1997 Aug;33(2):122-41. doi: 10.2165/00003088-199733020-00004. Clin Pharmacokinet. 1997. PMID: 9260035 Review.
Cited by
-
Homochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture.Nat Commun. 2019 May 24;10(1):2318. doi: 10.1038/s41467-019-10383-x. Nat Commun. 2019. PMID: 31127116 Free PMC article.
-
Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro.Br J Clin Pharmacol. 1993 Mar;35(3):235-42. doi: 10.1111/j.1365-2125.1993.tb05690.x. Br J Clin Pharmacol. 1993. PMID: 8385973 Free PMC article.
-
The beta 2-agonist controversy. Observations, explanations and relationship to asthma epidemiology.Drug Saf. 1994 Oct;11(4):259-83. doi: 10.2165/00002018-199411040-00005. Drug Saf. 1994. PMID: 7848546 Review.
-
The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.Am J Pathol. 2018 Feb;188(2):515-524. doi: 10.1016/j.ajpath.2017.10.018. Epub 2017 Nov 21. Am J Pathol. 2018. PMID: 29169987 Free PMC article.
-
Carbon dots based AuAg@AuNPs with oxidase-like activity for SERS dual-readouts detection of D-penicillamine.Mikrochim Acta. 2024 Sep 17;191(10):604. doi: 10.1007/s00604-024-06684-8. Mikrochim Acta. 2024. PMID: 39287838
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
