Review
doi: 10.1016/j.cell.2006.06.031.
Phagosome neutrality in host defense
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- PMID: 16839868
- DOI: 10.1016/j.cell.2006.06.031
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Review
Phagosome neutrality in host defense
Cell.
.
Free article
Abstract
Activation of proteases in the phagosomes of neutrophils occurs by neutralization of the phagosomal pH by NADPH oxidase. In this issue, Savina et al. (2006) show that dendritic cell phagosomes also recruit NADPH oxidase but with different results. Here, the neutralization of phagosomal pH reduces protease activity, which preserves antigens for crosspresentation on class I MHC molecules.
Comment on
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NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.Cell. 2006 Jul 14;126(1):205-18. doi: 10.1016/j.cell.2006.05.035. Cell. 2006. PMID: 16839887
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