Flipping riboswitches
- PMID: 16839869
- DOI: 10.1016/j.cell.2006.06.024
Flipping riboswitches
Abstract
Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this emerging field.
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