Review
doi: 10.1016/j.cell.2006.06.030.
OPA1 and PARL keep a lid on apoptosis
Affiliations
- PMID: 16839872
- DOI: 10.1016/j.cell.2006.06.030
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Review
OPA1 and PARL keep a lid on apoptosis
Cell.
.
Free article
Abstract
A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.
Comment on
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Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.Cell. 2006 Jul 14;126(1):163-75. doi: 10.1016/j.cell.2006.06.021. Cell. 2006. PMID: 16839884
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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.Cell. 2006 Jul 14;126(1):177-89. doi: 10.1016/j.cell.2006.06.025. Cell. 2006. PMID: 16839885
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