Review
doi: 10.1016/j.cell.2006.06.032.
p53 and metabolism: Inside the TIGAR
Affiliations
- PMID: 16839873
- DOI: 10.1016/j.cell.2006.06.032
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Review
p53 and metabolism: Inside the TIGAR
Cell.
.
Free article
Abstract
The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.
Comment on
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TIGAR, a p53-inducible regulator of glycolysis and apoptosis.Cell. 2006 Jul 14;126(1):107-20. doi: 10.1016/j.cell.2006.05.036. Cell. 2006. PMID: 16839880
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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.Cell. 2006 Jul 14;126(1):121-34. doi: 10.1016/j.cell.2006.05.034. Cell. 2006. PMID: 16839881
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