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. 1975 Aug;16(2):217-21.
doi: 10.1128/JVI.16.2.217-221.1975.

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis

H Ludwig, R Rott

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis

H Ludwig et al. J Virol. 1975 Aug.

Abstract

In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.

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References

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