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Review
. 2006 Feb;26(1):8-21.
doi: 10.1016/s0242-6498(06)70655-1.

[Molecular consequences of fixation and tissue processing: the examples of nucleic acids and proteins]

[Article in French]
François Plénat  1 , Karine Montagne, Nicolas Weinbreck, Sébastien Corby, Jacqueline Champigneulle, Laurent Antunes, Corinne Bonnet, Claudine Maire, Nathalie Monhoven
Affiliations
Review

[Molecular consequences of fixation and tissue processing: the examples of nucleic acids and proteins]

[Article in French]
François Plénat et al. Ann Pathol. 2006 Feb.

Abstract

The scientific usefulness of the molecular data obtained from tissue analysis is related directly to the quality of the tissue specimen. The most ideal tissue specimen is the one that carries a complete and unaltered representation of the tissue in vivo. The aim of this review is to provide an overview of the effects of fixation and tissue processing on the content and integrity of nucleic acid and proteins.

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