Review
doi: 10.2174/138955706777698606.
Fused 1,4-dihydropyridines as potential calcium modulatory compounds
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- PMID: 16842124
- DOI: 10.2174/138955706777698606
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Review
Fused 1,4-dihydropyridines as potential calcium modulatory compounds
Mini Rev Med Chem.
2006 Jul.
Abstract
1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium antagonistic activity. Fused 1,4-dihydropyridines (DHPs) have also exhibit calcium modulatory activities. In this article, we emphasize calcium channels and fused 1,4-DHP derivatives affecting calcium channels. In addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.
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