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Review
. 2006 Jul;62(1):35-46.
doi: 10.1111/j.1365-2125.2006.02591.x.

The role of pharmacogenetics in cancer therapeutics

Wei Peng Yong  1 , Federico Innocenti, Mark J Ratain
Affiliations
Review

The role of pharmacogenetics in cancer therapeutics

Wei Peng Yong et al. Br J Clin Pharmacol. 2006 Jul.

Abstract

The variability in treatment responses and narrow therapeutic index of anticancer drugs are some of the key challenges oncologists face. The knowledge of pharmacogenetics can potentially aid in the discovery, development and ultimately individualization of anticancer drugs. The identification of genetic variations that predict for drug response is the first step towards the translation of pharmacogenetics into clinical practice. This review provides an update on the results of studies assessing the effects of germline polymorphisms and somatic mutations on therapeutic outcomes and highlights the potential applications and future challenges in pharmacogenetic research pertaining to cancer therapeutics.

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