Case Reports
doi: 10.1016/j.cancergencyto.2006.02.013.
Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia
Affiliations
- PMID: 16843104
- DOI: 10.1016/j.cancergencyto.2006.02.013
Item in Clipboard
Case Reports
Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia
Cancer Genet Cytogenet.
.
Abstract
Rearrangements of the mixed-lineage leukemia (MLL) gene have been associated with a poor prognosis in infant acute lymphoblastic leukemia (ALL). Previously, MLL translocations involving the CREP-binding protein (CREBBP) gene at chromosome band 16p13.3 have primarily been reported in treatment-related acute myeloid leukemia, after chemotherapy for other primary malignancies using topoisomerase II inhibitors. We report a case of de novo infant ALL with t(11;16)(q23;p13.3). After chemotherapy, this patient developed an acute monoblastic leukemia (M5b) with retention of the t(11;16)(q23;p13.3), indicating that this is a lineage switch of the original leukemic clone. To our knowledge, these findings have not been previously reported.
Similar articles
-
Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.Leuk Res. 2010 Aug;34(8):1107-9. doi: 10.1016/j.leukres.2010.02.029. Epub 2010 Mar 17. Leuk Res. 2010. PMID: 20299091
-
Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36).Haematologica. 2005 May;90(5):602-11. Haematologica. 2005. PMID: 15921375
-
[Establishment and characterization of a human acute monocytic leukemic cell line, SHI-1, carrying t(6;11)(q27;23) and p53 gene alteration].Zhonghua Xue Ye Xue Za Zhi. 2005 Feb;26(2):94-9. Zhonghua Xue Ye Xue Za Zhi. 2005. PMID: 15921626 Chinese.
-
Translocation (8;18;16)(p11;q21;p13). A new variant of t(8;16)(p11;p13) in acute monoblastic leukemia: case report and review of the literature.Cancer Genet Cytogenet. 2006 Feb;165(1):75-8. doi: 10.1016/j.cancergencyto.2005.10.017. Cancer Genet Cytogenet. 2006. PMID: 16490600 Review.
-
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.Cancer Genet Cytogenet. 2004 Jul 15;152(2):108-12. doi: 10.1016/j.cancergencyto.2003.11.012. Cancer Genet Cytogenet. 2004. PMID: 15262427 Review.
Cited by
-
B-cell acute lymphoblastic leukemia with t(4;11)(q21;q23) in a young woman: evolution into mixed phenotype acute leukemia with additional chromosomal aberrations in the course of therapy.Hematol Rep. 2012 Jul 11;4(3):e15. doi: 10.4081/hr.2012.e15. Epub 2012 Sep 6. Hematol Rep. 2012. PMID: 23087804 Free PMC article.
-
Clonal Evolution of B-Cell Acute Lymphoblastic Leukemia with del(9)(p13p21) into Mixed Phenotype Acute Leukemia Presenting as an Isolated Testicular Relapse.Reports (MDPI). 2019 Sep;2(3):18. doi: 10.3390/reports2030018. Epub 2019 Jul 15. Reports (MDPI). 2019. PMID: 38370916 Free PMC article.
-
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.Leukemia. 2014 Mar;28(3):609-20. doi: 10.1038/leu.2013.354. Epub 2013 Nov 25. Leukemia. 2014. PMID: 24270736
-
Precision Medicine Approaches in Acute Myeloid Leukemia with Adverse Genetics.Int J Mol Sci. 2024 Apr 11;25(8):4259. doi: 10.3390/ijms25084259. Int J Mol Sci. 2024. PMID: 38673842 Free PMC article. Review.
-
Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia.Ann Hematol. 2021 Jan;100(1):63-78. doi: 10.1007/s00277-020-04114-2. Epub 2020 Jun 16. Ann Hematol. 2021. PMID: 32556451
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
