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. 1991;77(3-4):257-67.

GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist

G Rabloczky  1 , L Jaszlits, E Horváth
Affiliations
  • PMID: 1684485

GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist

G Rabloczky et al. Acta Physiol Hung. 1991.

Abstract

Using the pithed rat preparation it has been proven that GYKI-12743 exerted its alpha-adrenergic blocking action only at the postsynaptic vascular level in the cardiovascular system. This new molecule failed to antagonize the presynaptic alpha 2-adrenoceptors of the cardiac sympathetic nerve endings. Thereby it was possible to demonstrate the first vasoselective postsynaptic adrenoceptor antagonist which potentially might be interesting in the cardiovascular therapy.

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