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. 2006 Jul 1;34(Web Server issue):W683-5.
doi: 10.1093/nar/gkl299.

Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences

Vinod Scaria  1 , Manoj Hariharan, Amit Arora, Souvik Maiti
Affiliations

Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences

Vinod Scaria et al. Nucleic Acids Res. .

Abstract

G-quadruplex secondary structures, which play a structural role in repetitive DNA such as telomeres, may also play a functional role at other genomic locations as targetable regulatory elements which control gene expression. The recent interest in application of quadruplexes in biological systems prompted us to develop a tool for the identification and analysis of quadruplex-forming nucleotide sequences especially in the RNA. Here we present Quadfinder, an online server for prediction and bioinformatics of uni-molecular quadruplex-forming nucleotide sequences. The server is designed to be user-friendly and needs minimal intervention by the user, while providing flexibility of defining the variants of the motif. The server is freely available at URL http://miracle.igib.res.in/quadfinder/.

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Figures

Figure 1
Figure 1
Input options for Quadfinder. The user is asked to input the nucleotide sequences along with the minimum and maximum values of G-stretches and loop lengths.
Figure 2
Figure 2
Output display of Quadfinder. This page displays the positive hits along with options to further analyze the motif. The user also has the convenience to download the result files.
See this image and copyright information in PMC

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