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. 2006 Aug;7(8):665-74.
doi: 10.1631/jzus.2006.B0665.

Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea

S Brijesh  1 , P G Daswani, P Tetali, S R Rojatkar, N H Antia, T J Birdi
Affiliations

Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea

S Brijesh et al. J Zhejiang Univ Sci B. 2006 Aug.

Abstract

While data are available on the effect of medicinal plants on intestinal motility and their antibacterial action, there is a paucity of information on their mode of action on various aspects of diarrheal pathogenicity, namely colonization to intestinal epithelial cells and production/action of enterotoxins. Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial (antibacterial, antigiardial and antirotaviral) effect; and its effect on production and action of enterotoxins (cholera toxin, CT; Escherichia coli labile toxin, LT; and E. coli stable toxin, ST); and adherence of enteropathogenic E. coli and invasion of enteroinvasive E. coli and Shigella flexneri to epithelial cells. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells. The observed results indicated that the crude decoction of P. pinnata has selective antidiarrheal action with efficacy against cholera and enteroinvasive bacterial strains causing bloody diarrheal episodes.

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Figures

Fig. 1
Fig. 1
Antigiardial activity of decoction of Pongamia pinnata leaves The bars represent mean±standard deviation (from three individual experiments) of percentage reduction in viability of trophozoites as compared to respective value of controls (100%); C: Trophozoites incubated without the decoction was used as a control; M: Metronidazole (100 μg/ml) was used as a positive control
Fig. 2
Fig. 2
Antirotaviral activity of decoction of Pongamia pinnata leaves The bars represent mean±standard deviation (from three individual experiments) of percentage optical density as compared to respective value of controls (100%); C: Uninfected MA-104 cells incubated without the decoction was used as a control; RV: Rotavirus infected MA-104 cells
Fig. 3
Fig. 3
HPLC profiles of water decoction (a) and acetone extract (b) of Pongamia pinnata leaves. The related parameters are given in detail in Table 5
Fig. 3
Fig. 3
HPLC profiles of water decoction (a) and acetone extract (b) of Pongamia pinnata leaves. The related parameters are given in detail in Table 5
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