doi: 10.1385/1-59745-037-5:449.
Identification of genes involved in tumor-like properties of embryonic stem cells
Affiliations
- PMID: 16846009
- DOI: 10.1385/1-59745-037-5:449
Item in Clipboard
Identification of genes involved in tumor-like properties of embryonic stem cells
Methods Mol Biol.
2006.
Abstract
Embryonic stem (ES) cells are pluripotent stem cells derived from preimplantation stage embryos. ES cells proliferate infinitely while maintaining pluripotency. These properties make them attractive sources for stem cell therapies and regenerative medicine. However, undifferentiated ES cells produce tumors when transplanted, which may preclude their therapeutic usage. It is largely unknown why ES cells can possess tumorigenicity without having chromosomal abnormalities. In this chapter, we introduce the methods to identify genes that play roles in tumor-like properties of ES cells.
Similar articles
-
In vivo tumor formation from primate embryonic stem cells.Methods Mol Biol. 2006;329:459-67. doi: 10.1385/1-59745-037-5:459. Methods Mol Biol. 2006. PMID: 16846010
-
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.Nature. 2003 May 29;423(6939):541-5. doi: 10.1038/nature01646. Nature. 2003. PMID: 12774123
-
Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells.Stem Cells. 2006 Jun;24(6):1476-86. doi: 10.1634/stemcells.2005-0299. Epub 2006 Feb 2. Stem Cells. 2006. PMID: 16456129
-
Human embryonic stem cells and therapeutic cloning.J Vet Sci. 2005 Jun;6(2):87-96. J Vet Sci. 2005. PMID: 15933427 Review.
-
[Establishment of human embryonic stem cell lines and their therapeutic application].Rinsho Byori. 2004 Mar;52(3):254-8. Rinsho Byori. 2004. PMID: 15137326 Review. Japanese.
Cited by
-
Technological progress in generation of induced pluripotent stem cells for clinical applications.ScientificWorldJournal. 2012;2012:417809. doi: 10.1100/2012/417809. Epub 2012 Mar 12. ScientificWorldJournal. 2012. PMID: 22536140 Free PMC article. Review.
-
Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts.Neoplasia. 2009 Dec;11(12):1301-8. doi: 10.1593/neo.09850. Neoplasia. 2009. PMID: 20019838 Free PMC article.
-
PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone.Front Cell Neurosci. 2015 Mar 18;9:78. doi: 10.3389/fncel.2015.00078. eCollection 2015. Front Cell Neurosci. 2015. PMID: 25852474 Free PMC article.
-
Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.J Clin Invest. 2016 Aug 1;126(8):3104-16. doi: 10.1172/JCI85193. Epub 2016 Jul 18. J Clin Invest. 2016. PMID: 27427986 Free PMC article.
-
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells.Front Oncol. 2018 Oct 10;8:376. doi: 10.3389/fonc.2018.00376. eCollection 2018. Front Oncol. 2018. PMID: 30364132 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
