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. 2006 Jul 17:4:46.
doi: 10.1186/1477-7819-4-46.

Combining partial liver resection and local ablation of liver tumours: a preliminary Dutch experience

Bram Fioole  1 , Maarten C Jansen, Frederieke H van Duijnhoven, Richard van Hillegersberg, Thomas M van Gulik, Inne Hm Borel Rinkes
Affiliations

Combining partial liver resection and local ablation of liver tumours: a preliminary Dutch experience

Bram Fioole et al. World J Surg Oncol. .

Abstract

Background: The combination of partial liver resection and radiofrequency ablation (RFA) is a novel concept in the treatment of unresectable liver malignancies. The aim of this study is to evaluate the results of this combined strategy in the Netherlands.

Methods: Thirty-five patients treated with a combination of partial liver resection and RFA were identified from a prospectively registered pooled multicentre database. All patients were operated between June 1999 and November 2003 in 8 medical centres in The Netherlands. Main outcome parameters were morbidity, mortality, local success rate, and survival.

Results: Thirty-seven operations were performed in 35 patients. The group consisted of 20 male and 15 female patients with a median age of 59 years (range 41-76). Seventy-six lesions were resected and RFA was performed to ablate 82 unresectable liver tumours. Twelve patients developed a total of 24 complications, resulting in an overall perioperative morbidity rate of 32%. In two patients major complications resulted in postoperative death (postoperative mortality rate 5.4%). Local success rate after RFA was 88% and the estimated 1-, 2- and 3-year overall survival rates were 84%, 70% and 43%, respectively.

Conclusion: This strategy should only be performed following strict patient selection and within the context of prospective clinical trials.

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