Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer
- PMID: 16847382
- DOI: 10.1159/000094562
Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer
Abstract
Background/aims: Patients with pancreatic cancer have one of the poorest survival rates and selection of patients for active treatment remains problematical. The present study assesses the value of an inflammation-based score (Glasgow Prognostic Score, GPS) in patients with inoperable pancreatic cancer.
Methods: The GPS was constructed as follows: patients with both an elevated C-reactive protein (>10 mg/l) and hypoalbuminaemia (<35 g/l) were allocated a score of 2. Patients in whom only 1 or none of these biochemical abnormalities was present were allocated a score of 1 or 0, respectively.
Results: One hundred and eighty-seven patients were studied and 49 (26%) underwent an operative palliative bypass procedure. At the end of follow-up, 181 (97%) patients died, 17% of patients were alive at 12 months. On univariate analysis, age (p < 0.01), TNM stage (p < 0.001) and the GPS (p < 0.001) were significant predictors of survival. On multivariate survival analysis, stratified for bypass procedure, age (hazard ratio 1.53, 95%CI 1.12-2.10, p = 0.008), TNM stage (hazard ratio 1.70, 95%CI 1.33-2.18, p < 0.001) and the GPS (hazard ratio 1.72, 95%CI 1.40-2.11, p < 0.001) remained independent significant predictors of survival.
Conclusion: At diagnosis, the presence of a systemic inflammatory response (as measured by the GPS) appears to be a useful indicator of poor outcome, independent of TNM stage, in patients with inoperable pancreatic cancer.
Copyright (c) 2006 S. Karger AG, Basel and IAP.
Similar articles
-
Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer.Cancer. 2007 Jan 15;109(2):205-12. doi: 10.1002/cncr.22400. Cancer. 2007. PMID: 17149754
-
Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival.Nutr Cancer. 2006;55(1):78-85. doi: 10.1207/s15327914nc5501_10. Nutr Cancer. 2006. PMID: 16965244
-
Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG-ps) in patients receiving palliative chemotherapy for gastroesophageal cancer.J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e325-9. doi: 10.1111/j.1440-1746.2007.05105.x. Epub 2007 Jul 20. J Gastroenterol Hepatol. 2008. PMID: 17645468
-
The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer.Cancer Treat Rev. 2013 Aug;39(5):534-40. doi: 10.1016/j.ctrv.2012.08.003. Epub 2012 Sep 17. Cancer Treat Rev. 2013. PMID: 22995477 Review.
-
The prevalence of cancer associated systemic inflammation: Implications of prognostic studies using the Glasgow Prognostic Score.Crit Rev Oncol Hematol. 2020 Jun;150:102962. doi: 10.1016/j.critrevonc.2020.102962. Epub 2020 Apr 18. Crit Rev Oncol Hematol. 2020. PMID: 32344318 Review.
Cited by
-
Initial Metastatic Site as a Prognostic Factor in Patients With Stage IV Pancreatic Ductal Adenocarcinoma.Medicine (Baltimore). 2015 Jun;94(25):e1012. doi: 10.1097/MD.0000000000001012. Medicine (Baltimore). 2015. PMID: 26107667 Free PMC article.
-
Evaluation of inflammation-based markers for predicting the prognosis of unresectable pancreatic ductal adenocarcinoma treated with chemotherapy.Mol Clin Oncol. 2018 Oct;9(4):408-414. doi: 10.3892/mco.2018.1696. Epub 2018 Aug 10. Mol Clin Oncol. 2018. PMID: 30233794 Free PMC article.
-
Prognostic value of systemic inflammatory responses in patients with upper urinary tract urothelial carcinoma.World J Urol. 2015 Oct;33(10):1439-57. doi: 10.1007/s00345-015-1484-9. Epub 2015 Jan 20. World J Urol. 2015. PMID: 25600022
-
Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer.Int J Colorectal Dis. 2007 Aug;22(8):881-6. doi: 10.1007/s00384-006-0259-6. Epub 2007 Jan 24. Int J Colorectal Dis. 2007. PMID: 17245566
-
Inflammation-Based Prognostic Score Predicts Postoperative Survival of Patients with Interstitial Pneumonia After Undergoing Lung Cancer Resection.World J Surg. 2018 Jul;42(7):2143-2152. doi: 10.1007/s00268-017-4426-4. World J Surg. 2018. PMID: 29344688
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials