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. 2006 Jul;12(7):1175-6.
doi: 10.3201/eid1207.060234.

Small Anellovirus in hepatitis C patients and healthy controls

Elisabetta Andreoli, Fabrizio Maggi, Mauro Pistello, Silvia Meschi, Marialinda Vatteroni, Luca Ceccherini Nelli, Mauro Bendinelli

Small Anellovirus in hepatitis C patients and healthy controls

Elisabetta Andreoli et al. Emerg Infect Dis. 2006 Jul.
No abstract available

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Figures

Figure A1
Figure A1
Amino acid sequences of the small anellovirus (SAV) obtained in the present study (arrows show accession nos. DQ409192 to DQ409199). GI, TE, and GA were from healthy donors; FI, RI, BE, DF, and DT were from hepatitis C patients. The sequences are aligned with all SAV present in GenBank at the time of writing and with representative torquetenovirus (TTV) and torquetenominivirus (TTMV) isolates. ClustalW alignments were manually edited and trimmed to eliminate poorly aligned positions and reduce homoplasy. As evaluated by Motif Scan and ProtParam analyses, the sequences were found to share similar properties (e.g., hydrophobicity profile, theoretical isoelectric point), irrespective of viral species. The WX7HX3CXCX5H motif highly characteristic of the open reading frame 2 of anelloviruses is indicated by asterisks.
Figure A2
Figure A2
Amino acid sequences of the small anellovirus (SAV) obtained in the present study (arrows show accession nos. DQ409192 to DQ409199). GI, TE, and GA were from healthy donors; FI, RI, BE, DF, and DT were from hepatitis C patients. Evolutionary relationships between and within the 3 anelloviruses, torquetenovirus (TTV), torquetenominivirus (TTMV), and small anellovirus (SAV) are shown. Analysis is based on the 18 amino acid (aa) sequences of SAV above (75–104 aa), 46 open reading frame 2 (ORF2) amino acid sequences representative of the 5 TTV genogroups (96–104 aa), and 10 ORF2 amino acid sequences of TTMV (92–95 aa). Branching pattern was obtained by the FastME algorithm included in DAMBE software package (version 4.2.13). Bootstrap resampling was used to test the robustness of the tree, and bootstrap values >800 of 1,000 replicates are shown at the major branch points. The tree was drawn by the Treeview software (version 1.6.6). The ORF2 (110 aa) of porcine circovirus 2 was used as outgroup. Mean and range percentage amino acid distances within each of the 3 anelloviruses are shown in parentheses next to the virus names. Scale bar indicates the estimated number of amino acid substitutions per site.
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