doi: 10.1016/0168-1702(91)90080-f.
Repetitive nucleotide sequencing of a dispensable DNA segment in a clonal population of African swine fever virus
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- PMID: 1685049
- DOI: 10.1016/0168-1702(91)90080-f
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Repetitive nucleotide sequencing of a dispensable DNA segment in a clonal population of African swine fever virus
Virus Res.
1991 Aug.
Abstract
Repetitive nucleotide sequencing of a dispensable genomic segment of a clonal population of African swine fever (ASF) virus has been carried out to estimate the mutant frequency to neutral alleles. Since no mutations have been detected in a total of 54026 nucleotides screened, the maximum mutant frequency is 5.5 x 10(-5) substitutions/nucleotide (95% confidence level). The result renders very unlikely the occurrence of hypermutational events during ASF virus DNA replication, at least within the selected DNA fragment.
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