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Review
. 1991 Jun:93:41-4.
doi: 10.1289/ehp.919341.

Genetic changes during mouse skin tumorigenesis

P A Burns  1 , R Bremner, A Balmain
Affiliations
Review

Genetic changes during mouse skin tumorigenesis

P A Burns et al. Environ Health Perspect. 1991 Jun.

Abstract

This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrates that trisomy of chromosome 7 is an early event preceding papilloma formation, and further events, such as mitotic recombination, seem to occur during progression to malignant carcinomas. There is some evidence of a tumor-suppressor locus situated on chromosome 7.

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