Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jul 19;2006(3):CD003599.
doi: 10.1002/14651858.CD003599.pub2.

Diuretics for Ménière's disease or syndrome

A S Thirlwall  1 , S Kundu
Affiliations

Diuretics for Ménière's disease or syndrome

A S Thirlwall et al. Cochrane Database Syst Rev. .

Abstract

Background: Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. Diuretics are used to try and reduce the severity and frequency of episodes but there is little evidence behind this treatment.

Objectives: To assess the effect of diuretic treatment in patients with Ménière's disease.

Search strategy: We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1 2005), MEDLINE (1966 to 2005), EMBASE (1974 to 2005), CINAHL and the metaRegister of Controlled Trials (mRCT) (up to 2005).

Selection criteria: Randomised controlled trials of diuretic versus placebo in Ménière's patients.

Data collection and analysis: One author identified studies which loosely met the inclusion criteria and full texts were retrieved. Two authors independently applied the inclusion criteria. Seven studies were excluded from the review due to inappropriate study design or absence of randomisation.

Main results: There were no trials of high enough quality to meet the standard set for this review.

Authors' conclusions: There is insufficient good evidence of the effect of diuretics on vertigo, hearing loss, tinnitus or aural fullness in clearly defined Ménière's disease.

PubMed Disclaimer

Conflict of interest statement

None known.

Update of

  • doi: 10.1002/14651858.CD003599

References

References to studies excluded from this review

Brookes 1984 {published data only}
    1. Brookes GB, Booth JB. Oral acetazolamide in Meniere's disease. Journal of Laryngology and Otology 1984;98(11):1087‐95. - PubMed
Corvera 1989 {published data only}
    1. Corvera J, Corvera G. Long‐term effect of acetazolamide and chlorthalidone on the hearing loss of Meniere's Disease. American Journal of Otology 1989;10(2):142‐5. - PubMed
Kitahara 1982 {published data only}
    1. Kitahara M, Takeda T, Yazawa Y, Matsubara H, Kitano H. Treatment of Meniere's Disease with isosorbide. ORL. Journal of Otorhinolaryngology and its Related Specialties 1986;44(4):232‐8. - PubMed
Kitahara 1986 {published data only}
    1. Kitahara M, Watanabe I, Hinoki M, Mizukoshi K, Matsunaga T. Clinical study of isosorbide on Meniere's disease inter‐group comparative study with betahistine mesylate by multicentered double‐blind trial. Otologia Fukuoka 1986;32(1):44‐92.
Klockhoff 1967 {published data only}
    1. Klockhoff I, Lindblom U. Meniere's disease and hydrochlorothiazide (Dichlotride) ‐ a critical analysis of symptoms and therapeutic effects. Acta Oto‐laryngologica 1967;63(4):347‐65. - PubMed
Klockhoff 1974 {published data only}
    1. Klockhoff I, Lindblom U, Stahle J. Diuretic treatment of Meniere disease. Archives of Otolaryngology 1974;100(4):262‐5. - PubMed
Petermann 1982 {published data only}
    1. Petermann W, Mulch G. Long‐term therapy of Meniere's disease. Comparison of effects of betahistine dihydrochloride and hydrochlorothiazide. Fortschritte der Medizin 1982;100(10):431‐5. - PubMed
Ralli 1989 {published data only}
    1. Ralli G, Celestino D, Fabbricatore M, Gabini S, Taverniti L. Effect of acetazolamide on Meniere's disease. Acta Otorhinolaryngologica Italia 1989;9(5):503‐9. - PubMed
Van Deelen 1986 {published data only}
    1. Deelen G W, Huizing E H. Use of a diuretic (Dyazide) in the treatment of Meniere's Disease. ORL Journal for Otorhinolaryngology and its Related Specialties 1986;48(5):287‐92. - PubMed
Yamazaki 1988 {published data only}
    1. Yamazaki T, Ogawa K, Yamakawa M, Yamanaka N, Shirato M, Yanai T. Clinical evaluation of long‐term treatment of Meniere's disease with isosorbide multi‐centered double‐blind trial with betahistine mesylate as a reference drug. Otologia Fukuoka 1988;34(4):987‐1007.

Additional references

Alford 1972
    1. Alford BR. Menière's Disease: criteria for diagnosis and evaluation of therapy for reporting. Report of subcommittee on equilibrium and its measurement. Transactions of the American Academy of Ophthalmology and Otolaryngology 1972;76:1462‐4. - PubMed
da Costa 2002
    1. Costa SS, Sousa LC, Piza MR. Meniere's disease: overview, epidemiology and natural history. Otolaryngologic Clinics of North America 2002;35(3):455‐95. - PubMed
Hallpike 1938
    1. Hallpike C, Cairns H. Observations on the pathology of Menière's syndrome. Journal of Laryngology and Otology 1938;53:625‐55. - PMC - PubMed
Handbook 2008
    1. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane‐handbook.org.
James 2001
    1. James AL, Burton ML. Betahistine for Ménière's disease or syndrome. Cochrane Database of Systematic Reviews 2001, Issue 3. [Art. No.: CD001873. DOI: 10.1002/14651858.CD001873] - PMC - PubMed
Moffat 1997
    1. Moffat DA, Ballagh RH. Menière's Disease. In: Kerr AG, Booth JB editor(s). Scott‐Brown's Otolaryngology. 3rd Edition. Vol. 3, Oxford: Butterworth‐Heinemann, 1997:1‐50.
Morales 2003
    1. Morales Angulo C, Gomez Castellanos R, Garcia Mantlla J, Bezos Capelastegui JT, Carrera F. Epidemiology of Meniere's disease in Cantabria. Acta Otorrinolaringológica Española 2003;54(9):601‐5. - PubMed
Ménière's Guide 1995
    1. Committee on Hearing and Equilibrium. Guidelines for the diagnosis and evaluation of therapy in Menière’s disease. Otolaryngology ‐ Head and Neck Surgery 1995;113:181‐5. - PubMed
Pearson 1985
    1. Pearson BW, Brackmann DE. Committee on hearing and equilibrium guidelines for reporting treatment results in Menière's disease. Otolaryngology ‐ Head and Neck Surgery 1985;93:578‐81. - PubMed
Schulz 1995
    1. Schultz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408‐12. - PubMed
Silverstein 1989
    1. Silverstein H, Smouha E, Jones R. Natural history versus surgery for Menière's disease. Otolaryngology ‐ Head and Neck Surgery 1989;100:6‐16. - PubMed
Takeda 1998
    1. Takeda N, Koizuka I, Kitihara T, Horii A, Uno A, Taya N, et al. Clinical features in patients with delayed endolymphatic hydrops. Nippon Jibinkoka Gakkai Kaiho 1998;101(12):1385‐9. - PubMed
Watanabe 1995
    1. WatanabeY, Mizukoshi K, Shojaku H, Watanabe I, Hinoki M, Kitahara M. Epidemiological and clinical characteristics of Meniere's disease in Japan. Acta Oto‐laryngologica Supplementum 1995;519:206‐10. - PubMed

Publication types