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. 2006 Oct;77(4):338-40.
doi: 10.1111/j.1600-0609.2006.00713.x. Epub 2006 Jul 19.

Rapid infusion of rituximab with or without steroid-containing chemotherapy: 1-yr experience in a single institution

Antonio Salar  1 , Dolors Casao, Marta Cervera, Carmen Pedro, Montserrat Calafell, Eugenia Abella, Alberto Alvarez-Larrán, Carlos Besses
Affiliations

Rapid infusion of rituximab with or without steroid-containing chemotherapy: 1-yr experience in a single institution

Antonio Salar et al. Eur J Haematol. 2006 Oct.

Abstract

We assessed the feasibility of a rapid infusion of rituximab with or without steroid-containing chemotherapy.

Inclusion criteria: previous infusion of rituximab without grade 3 or 4 toxicity, lymphoid cells <5 x 10(9)/L and rituximab dose of 375 mg/m(2). Seventy patients were treated with a total of 319 rapid rituximab infusions [126 (40%) with and 193 (60%) without steroids]. Overall, rapid infusion of rituximab was well tolerated - there were no grade 3 or 4 adverse events. Only, three patients developed symptoms, all grade 1. In conclusion, rituximab administration in a 90-min infusion schedule is well tolerated and safe, both in patients who are administered steroids and in patients who are not.

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