doi: 10.1016/j.it.2006.07.003.
Epub 2006 Jul 18.
NF-kappaB activation: Nondegradative ubiquitination implicates NEMO
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- PMID: 16857427
- DOI: 10.1016/j.it.2006.07.003
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NF-kappaB activation: Nondegradative ubiquitination implicates NEMO
Trends Immunol.
2006 Sep.
Abstract
Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.
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