Review
doi: 10.1016/j.molcel.2006.07.002.
Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated
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- PMID: 16857579
- DOI: 10.1016/j.molcel.2006.07.002
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Review
Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated
Mol Cell.
.
Free article
Abstract
Targeting proteins for irreversible degradation must be under tight control and is often regulated at the level of substrate-receptor binding. But does a protein really need to be marked twice with two different modifications, first phosphorylation and then isomerization, to bind its receptor, as van Drogen et al. (2006) show for cyclin E?
Comment on
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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.Mol Cell. 2006 Jul 7;23(1):37-48. doi: 10.1016/j.molcel.2006.05.020. Mol Cell. 2006. PMID: 16818231
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