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Review
. 2006 Jul 21;23(2):149-50.
doi: 10.1016/j.molcel.2006.07.002.

Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated

Stuart D Shumway  1 , Yue Xiong
Affiliations
Free article
Review

Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated

Stuart D Shumway et al. Mol Cell. .
Free article

Abstract

Targeting proteins for irreversible degradation must be under tight control and is often regulated at the level of substrate-receptor binding. But does a protein really need to be marked twice with two different modifications, first phosphorylation and then isomerization, to bind its receptor, as van Drogen et al. (2006) show for cyclin E?

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