Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 May;72(5):1843-7.
doi: 10.1073/pnas.72.5.1843.

Folding of the DNA double helix in chromatin-like structures from simian virus 40

J E Germond, B Hirt, P Oudet, M Gross-Bellark, P Chambon

Folding of the DNA double helix in chromatin-like structures from simian virus 40

J E Germond et al. Proc Natl Acad Sci U S A. 1975 May.

Abstract

Relaxed circular, covalently closed simian virus 40 DNA molecules were associated with the four histones that are present in virions. In electron micrographs the resulting complexes appear twisted, with globular structures (nucleosomes) along the DNA. Incubation with an untwisting extract converts the twisted complexes to relaxed structures. Extraction of the DNA from the relaxed complexes yields supercoiled molecules. The number of superhelical turns in these molecules corresponds to the number of nucleosomes per DNA molecule in the complexes.

PubMed Disclaimer

References

    1. Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:199-208 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:235-41 - PubMed
    1. Science. 1975 Jan 17;187(4172):173-5 - PubMed
    1. Cell. 1975 Apr;4(4):281-300 - PubMed
    1. Nature. 1975 Jan 24;253(5489):245-9 - PubMed

LinkOut - more resources