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Review
. 2006 Aug;7(8):774-8.
doi: 10.1038/sj.embor.7400759. Epub 2006 Jul 21.

Alarmin(g) news about danger: workshop on innate danger signals and HMGB1

Helena Erlandsson Harris  1 , Angela Raucci
Affiliations
Review

Alarmin(g) news about danger: workshop on innate danger signals and HMGB1

Helena Erlandsson Harris et al. EMBO Rep. 2006 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Release of alarmins into extracellular space. High-mobility-group box 1 (HMGB1), and possibly other alarmins or danger-associated molecular patterns (DAMPs), is actively secreted by inflammatory cells and passively released by necrotic cells. By contrast, HMGB1 is irreversibly bound to the chromatin of apoptotic cells. Once in the extracellular environment, HMGB1 activates target cells by signalling through the receptor for advanced glycation end products (RAGE), toll-like receptor 2 (TLR2) or TLR4. HMGB1 might also cooperate with TLR ligands, such as bacterial DNA or lipopolysaccharide, for TLR activation. RAGE might be involved in these phenomena.
None
Helena Erlandsson Harris
None
Angela Raucci
None
The EMBO Workshop on Innate Danger Signals and HMGB1 took place between 8 and 11 February 2006 in Milan, Italy, and was organized by M. Bianchi, K. Tracey and U. Andersson.
See this image and copyright information in PMC

References

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