doi: 10.3181/00379727-149-38824.
Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to Concanavallin A
- PMID: 168587
- DOI: 10.3181/00379727-149-38824
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Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to Concanavallin A
Proc Soc Exp Biol Med.
1975 Jun.
Abstract
Spleen cells from nonlethally MCMV-infected weanling and adult DBA/2 mice had diminished responses to Con A stimulation. In contrast, only lethal MCMV infections were associated with a complete suppression of the Con A response. The immune response to SRBC was depressed even in asymptomatic infections of weanling and adult mice. A marked maturation of resistance to the lethal effects of MCMV infection was found to occur during the fourth week of life.
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