Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Mar;88(1-2):147-55.
doi: 10.1016/j.biosystems.2006.05.004. Epub 2006 May 26.

The clearance of BNP modeled using the NT-proBNP-BNP relationship

Martin H Kroll  1 , Pornpen Srisawasdi
Affiliations

The clearance of BNP modeled using the NT-proBNP-BNP relationship

Martin H Kroll et al. Biosystems. 2007 Mar.

Abstract

Background: The ventricular myocardium simultaneously secretes two natriuretic peptides useful in the evaluation of heart failure: BNP, hormonally active, and NT-proBNP, the N-terminal end, non-hormonally active, but ultimately their concentrations differ and their clearance patterns are poorly defined.

Methods: We measured NT-proBNP and BNP in patients with and without heart failure and compared their concentrations using regression analysis.

Results: The relationship between NT-proBNP with BNP is nonlinear. Between 45 and 70 pmol of BNP/L (class II heart failure) the slope is much higher than in other ranges and the NT-proBNP/BNP ratio reaches its maximum in patients with class II NYHA heart failure.

Conclusions: The difference in concentration for NT-proBNP and BNP can be related to the diffusion across the renal basement membrane. Their ratio is nonlinear because BNP is cleared faster than in patients with class II heart failure than other classes or normal, suggesting a change in a non-renal mode of clearance.

PubMed Disclaimer

Substances

LinkOut - more resources