[Synthesis and evaluation of central nervous system activity of new triaza-spirodecanediones]

Abstract

It has been possible to prepare from 8-(2-phenylethyl)-1,3,8-triaza [4, 5] spirodecane-2,4-dione a new series of derivatives substituted on the nitrogen atom in the 3-position of the hydantoïn ring. Several compounds exhibited sedative, anticonvulsant and anxiolytic activities. The aryl or heteroaryl-piperazinomethyl substituted compounds were the most active derivatives. "Buspirone-like" anxiolytic effects were found in some compounds from 5 mg/kg dose per os.