Review
doi: 10.1016/0167-5699(91)90019-p.
X-linked immunodeficiencies: clues to genes involved in T- and B-cell differentiation
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- PMID: 1686172
- DOI: 10.1016/0167-5699(91)90019-p
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Review
X-linked immunodeficiencies: clues to genes involved in T- and B-cell differentiation
Immunol Today.
1991 Dec.
Abstract
There are five major human X-linked immunodeficiencies, each with a characteristic impairment of T-and/or B-cell differentiation. The molecular bases of these diseases remain unknown but, as Geneviève de Saint Basile and Alain Fischer report, major steps towards that goal have been taken: the location of the defective genes has been precisely defined and the cell lineages and stages of differentiation in which the genes are expressed have been partly identified.
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