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Comparative Study
. 2006 Aug;12(8):905-7.
doi: 10.1038/nm1456. Epub 2006 Jul 23.

A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

Amin Moghaddam  1 , Wieslawa Olszewska, Belinda Wang, John S Tregoning, Rebecca Helson, Quentin J Sattentau, Peter J M Openshaw
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Free article
Comparative Study

A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

Amin Moghaddam et al. Nat Med. 2006 Aug.
Free article

Abstract

Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with atypical enhanced disease during subsequent infection with paramyxoviruses. We show that carbonyl groups on formaldehyde-treated vaccine antigens boost T helper type 2 (T(H)2) responses and enhance respiratory syncytial virus (RSV) disease in mice, an effect partially reversible by chemical reduction of carbonyl groups.

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