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. 2006;2006(1):17898.
doi: 10.1155/MI/2006/17898.

Circulating total and active metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in patients with systemic lupus erythomatosus

Ewa Robak  1 , Agnieszka Wierzbowska, Magdalena Chmiela, Liliana Kulczycka, Anna Sysa-Jedrejowska, Tadeusz Robak
Affiliations

Circulating total and active metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in patients with systemic lupus erythomatosus

Ewa Robak et al. Mediators Inflamm. 2006.

Abstract

We investigated the serum concentration of total metalloproteinase-9 (tMPP-9), active MMP-9 (aMMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP-9 and TIMP-1 were assessed by an enzyme-linked immunosorbent assay (ELISA) and aMMP-9 by fluorometric assay. The tMMP-9 level was lower in SLE patients (mean 262 ng/mL) than in healthy volunteers (mean 325 ng/mL) (P = .048). Similarly, aMMP-9 level was lower in SLE patients (mean 121 ng/mL) than in control group (mean 169 ng/mL) (P = .0355) and lower in active SLE (mean 54 ng/mL) than in inactive disease (mean 99 ng/mL) (P = .033). TIMP-1 level was also lower in SLE patients (mean 181 ng/mL) than in control group (mean 233 ng/mL) (P = .004). In SLE patients, a positive correlation was found between tMMP-9 and aMMP-9 (rho = 0.568; P = .001). We also found a positive correlation of tMMP-9 and TIMP-1 with VEGF concentrations (rho = 0.450, P = .005 and rho = 0.387; P = .018, resp). tMMP-9, aMMP-9, and TIMP-1 serum levels are lower in SLE patients than in healthy control group.

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Figures

Figure 1
Figure 1
Correlations between total and active MMP-9 in SLE patients.
Figure 2
Figure 2
Correlations between VEGF and MMP-9 total, MMP-9 active, and TIMP-1 serum levels.
See this image and copyright information in PMC

References

    1. Pisetsky DS, Gilkeson G, St Clair EW. Systemic lupus erythematosus. Diagnosis and treatment. Medical Clinics of North America. 1997;81(1):113–128. - PubMed
    1. Swaak AJ, Nossent JC, Smeenk RJ. Systemic lupus erythematosus. International Journal of Clinical & Laboratory Research. 1992;22(4):190–195. - PubMed
    1. Walchner M, Meurer M, Plewig G, Messer G. Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus. International Journal of Dermatology. 2000;39(5):383–388. - PubMed
    1. Robak E, Wozniacka A, Sysa-Jedrzejowska A, Stepien H, Robak T. Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. European Cytokine Network. 2001;12(3):445–452. - PubMed
    1. Belmont HM, Abramson SB, Lie JT. Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium. Arthritis & Rheumatism. 1996;39(1):9–22. - PubMed

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