Case Reports
doi: 10.1111/j.1526-4610.2006.00514_1.x.
Melatonin responsive hemicrania continua
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- PMID: 16866728
- DOI: 10.1111/j.1526-4610.2006.00514_1.x
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Case Reports
Melatonin responsive hemicrania continua
Headache.
2006 Jul-Aug.
Abstract
Hemicrania continua is one of the indomethacin-responsive headache syndromes. There are very few effective alternative therapies for hemicrania continua, thus patients may require daily indomethacin for years. The risks of long-term indomethacin include gastrointestinal and renal dysfunction. Melatonin is a pineal hormone with a chemical structure very similar to indomethacin. Recently, melatonin was shown to be effective for primary stabbing headache, another indomethacin-responsive syndrome. Three cases of melatonin responsive hemicrania continua are now reported.
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