Case Reports
doi: 10.1016/j.humpath.2006.02.019.
Epub 2006 May 22.
Molecular diagnosis of Nocardia farcinica from a cerebral abscess
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- PMID: 16867876
- DOI: 10.1016/j.humpath.2006.02.019
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Case Reports
Molecular diagnosis of Nocardia farcinica from a cerebral abscess
Hum Pathol.
2006 Aug.
Abstract
Histopathology and special stains of a brain biopsy specimen from a 42-year-old man revealed numerous gram-positive bacilli arranged in branching filaments, suggesting Nocardia infection. Antibiotic therapy with trimethoprim-sulfamethoxazole markedly decreased the abscess size, and the patient improved. DNA was analyzed from formalin-fixed sections of the cerebral abscess by a 16S ribosomal DNA polymerase chain reaction assay demonstrating the presence of either Nocardia farcinica or N otitidiscaviarum. A species-specific polymerase chain reaction assay confirmed N farcinica as the etiologic agent.
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