Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Dec;77(12):1373-5.
doi: 10.1136/jnnp.2006.090415. Epub 2006 Jul 25.

Acute zonal occult outer retinopathy and multiple sclerosis

R Q Hintzen  1 , L I van den Born
Affiliations
Case Reports

Acute zonal occult outer retinopathy and multiple sclerosis

R Q Hintzen et al. J Neurol Neurosurg Psychiatry. 2006 Dec.

Abstract

The case of a 30-year-old woman who had two episodes of photopsia along with sudden-onset monocular visual field defects, developing into bilateral tunnel vision within 4 years, is reported. She also had episodes of a right hemiparesis and right-sided hypoaesthesia, accompanied by severe fatigue. This patient fulfilled the criteria for both clinically definite multiple sclerosis and acute zonal occult outer retinopathy (AZOOR). AZOOR can have an onset with monocular visual field loss, and can be distinguished from optic neuritis. In addition, some observations suggest common neuropathological and inflammatory mechanisms between multiple sclerosis and AZOOR.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None.

References

    1. Gass J D, Agarwal A, Scott I U. Acute zonal occult outer retinopathy: a long‐term follow‐up study. Am J Ophthalmol 2002134329–339. - PubMed
    1. Jampol L M, Becker K G. White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of the autoimmune/inflammatory disease. Am J Ophthalmol 2003135376–379. - PubMed
    1. Compston A, Coles A. Multiple sclerosis. Lancet 20023591221–1231. - PubMed
    1. Jacobson J D. Acute zonal occult outer retinopathy and central nervous system inflammation. J Neuroophthalmol 199616172–177. - PubMed
    1. Buljevac D, Flach H Z, Hop W C J.et al Prospective study on the relation between infections and multiple sclerosis exacerbations. Brain 2002125952–960. - PubMed

Publication types