Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Aug;50(8):2863-5.
doi: 10.1128/AAC.00449-06.

New integron-associated gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase

Renee S Levings  1 , Diane Lightfoot, Liam D H Elbourne, Steven P Djordjevic, Ruth M Hall
Affiliations
Comparative Study

New integron-associated gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase

Renee S Levings et al. Antimicrob Agents Chemother. 2006 Aug.

Abstract

A sixth gene cassette containing a dfrB-type gene, dfrB6, was found in a dfrB6-aadA1 cassette array in class 1 integrons. This array was isolated from several multiply antibiotic-resistant Salmonella enterica serovar Infantis strains that appear to be clonally related. The DfrB6 dihydrofolate reductase conferred resistance to trimethoprim.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Alignment of DfrB proteins. Amino acids completely conserved in all sequences are shown as white on black. The sequences were obtained from GenBank accession numbers listed in Table 1.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alonso, H., and J. E. Gready. 2006. Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme. Trends Microbiol. 14:236-242. - PubMed
    1. Collis, C. M., and R. M. Hall. 1995. Expression of antibiotic resistance genes in the integrated cassettes of integrons. Antimicrob. Agents Chemother. 39:155-162. - PMC - PubMed
    1. Grape, M., A. Farra, G. Kronvall, and L. Sundström. 2005. Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria. Clin. Microbiol. Infect. 11:185-192. - PubMed
    1. Grape, M., L. Sundström, and G. Kronvall. 2003. New dfr2 gene as a single-gene cassette in a class 1 integron from a trimethoprim-resistant Escherichia coli isolate. Microb. Drug Resist. 9:317-322. - PubMed
    1. Howell, E. E. 2005. Searching sequence space: two different approaches to dihydrofolate reductase catalysis. ChemBioChem 6:590-600. - PubMed

Publication types

MeSH terms

LinkOut - more resources