The over-expression of P-glycoprotein in K-562 and DAUDI cells, is associated with a high susceptibility to NK and LAK cells
Affiliations
- PMID: 1687102
Item in Clipboard
The over-expression of P-glycoprotein in K-562 and DAUDI cells, is associated with a high susceptibility to NK and LAK cells
J Biol Regul Homeost Agents.
1991 Oct-Dec.
Abstract
We evaluated the susceptibility to natural killer (NK) or lymphokine activated killer (LAK) cell-mediated cytolysis of two pairs of drug sensitive/resistant tumor cell lines which were extensively characterized at phenotypic and genotypic level. In the DAUDI cell system, the acquired capability of tumor cell variants to grow in the presence of a relatively high concentration of vinblastine (VBL) is associated with a marked increase to NK and LAK susceptibility. In contrast in the K-562 cell system, no correlation between drug-resistance, P-glycoprotein expression and susceptibility to NK or LAK activity seems to occur.
Similar articles
-
Human tumor cell line resistance to chemotherapeutic agents does not predict resistance to natural killer or lymphokine-activated killer cell-mediated cytolysis.Cancer Res. 1990 Sep 15;50(18):5931-6. Cancer Res. 1990. PMID: 1975512
-
Cytokines alter target cell susceptibility to lysis: I. Evaluation of non-major histocompatibility complex-restricted effectors reveals differential effects on natural and lymphokine-activated killing.J Biol Response Mod. 1990 Apr;9(2):113-26. J Biol Response Mod. 1990. PMID: 2111373
-
Susceptibility of multidrug-resistant human T-lymphoblastoid CEM cell line to cell-mediated cytolysis.Ann Ist Super Sanita. 1990;26(3-4):433-9. Ann Ist Super Sanita. 1990. PMID: 1982604
-
P-glycoprotein-mediated multidrug resistance and cytotoxic effector cells.Nat Immun. 1992 Jul-Aug;11(4):177-92. Nat Immun. 1992. PMID: 1358293 Review.
-
Resistance of multidrug-resistant lines to natural killer-like cell-mediated cytotoxicity.FASEB J. 1988 Sep;2(12):2791-6. doi: 10.1096/fasebj.2.12.3044904. FASEB J. 1988. PMID: 3044904 Review.
Cited by
-
Cellular models for multiple drug resistance in cancer.In Vitro Cell Dev Biol. 1993 Mar;29A(3 Pt 1):171-9. doi: 10.1007/BF02634176. In Vitro Cell Dev Biol. 1993. PMID: 8096505 Review. No abstract available.